Comprehensive Phylogenetic Analysis of Bacterial Reverse Transcriptases

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Comprehensive Phylogenetic Analysis of Bacterial Reverse Transcriptases

Much less is known about reverse transcriptases (RTs) in prokaryotes than in eukaryotes, with most prokaryotic enzymes still uncharacterized. Two surveys involving BLAST searches for RT genes in prokaryotic genomes revealed the presence of large numbers of diverse, uncharacterized RTs and RT-like sequences. Here, using consistent annotation across all sequenced bacterial species from GenBank an...

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References 1. Laube N, Pullmann M, Hergarten S, Hesse A. Influence of urinary stones on the composition of a 24-hour urine sample. Clin Chem 2003;49:281–5. 2. Laube N, Pullmann M, Hergarten S, Schmidt M, Hesse A. The alteration of urine composition due to stone material present in the urinary tract. Eur Urol 2003;44:595–9. 3. Hesse A, Brändle E, Wilbert D, Köhrmann KU, Alken P. Study on the pre...

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A diversity of uncharacterized reverse transcriptases in bacteria

Retroelements are usually considered to be eukaryotic elements because of the large number and variety in eukaryotic genomes. By comparison, reverse transcriptases (RTs) are rare in bacteria, with only three characterized classes: retrons, group II introns and diversity-generating retroelements (DGRs). Here, we present the results of a bioinformatic survey that aims to define the landscape of R...

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Reverse transcriptases (RTs) are usually thought of as eukaryotic enzymes, but they are also present in bacteria and likely originated in bacteria and migrated to eukaryotes. Only three types of bacterial retroelements have been substantially characterized: group II introns, diversity-generating retroelements, and retrons. Recent work, however, has identified a myriad of uncharacterized RTs and...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2014

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0114083